Modelling Trafficking of Proteins within the Mammalian Cell Using Bio-PEPA

Src: An oncoprotein, implicated in tumour formation and motility of cells; specifically, a non-receptor tyrosine kinase (Src, aSrc). FGF: A growth factor that is involved in signalling between cells. FGF receptor: A protein that sit across the membrane of the cell and to which FGF can bind. It transfers signals outside the cell to signalling pathways within the cell (FGFR). FGFR complex: A complex consisting of a dimer of FGF and FGFR, together with active Src and other species (FGFRc). Endosome: A membrane-bound compartment that transports molecules around the cell, moving along microtubules. Inactive: A protein in a conformation that makes it unable to interact with other molecules. Both phosphorylation and dephosphorylation can cause activation. Experiment: addition of FGF at high and low concentration